Alzheimer disease (AD) is the sixth leading cause of death in the US, but existing treatments provide only a modest improvement in symptoms. To our knowledge, no approved treatment exists that improves the course of disease or underlying pathology. Research on disease-modifying AD treatments has proven to be extremely challenging, with a number of major recent clinical trials of drug therapies resulting in negative or ambivalent findings.1,2 While many alternative ideas for developing a treatment for AD are being pursued, 2 key strategies have emerged: initiating interventions earlier in the course of disease in individuals who are at risk but unimpaired and identifying targets beyond abnormal amyloid and tau proteins, the pathology that defines AD.
Landau SM, Harrison TM. A Link Between Cardiovascular Risk Management and Alzheimer Disease Is Still Elusive. JAMA Neurol. 2021;78(5):524–526. doi:10.1001/jamaneurol.2021.0083
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