[Skip to Navigation]
Views 1,821
Citations 0
Images in Neurology
May 24, 2021

Dynamic Tremor in a Patient With Parkinson Disease

Author Affiliations
  • 1Functional Neurosurgery Division, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil
  • 2Movement Disorders Center, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil
JAMA Neurol. 2021;78(8):1015. doi:10.1001/jamaneurol.2021.1431

A 52-year-old man with Parkinson disease for 17 years came to our service with a 1-month history of sudden-onset resting tremor in the left upper limb only when lifting the contralateral limb (Video, segment 1). Four years prior, because of his motor fluctuations, he had deep brain stimulation (DBS) of the subthalamic nucleus implanted (St Jude Medical Libra XP), with good symptomatic control. During rest, despite signs of parkinsonism (bradykinesia and rigidity), no tremor was evident. When he moved the implantable pulse generator, the tremor reemerged (Video, segment 2). At the time, his medication regimen included only levodopa, 200 mg, 5 times a day every 2.5 hours. The impedance of the DBS system revealed high values in all contacts of the right electrode. However, examination and a series of plain radiographs did not reveal macroscopic defects (Figure). Dynamic disconnection in the pulse generator was suspected, and the DBS system was revised. During the review, a misconnection was found between the connection cable and the implantable pulse generator. After surgery (implantable pulse generator exchange), the patient showed immediate improvement.

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words