In the field of epilepsy treatment, we are often caught between the proverbial rock and hard place: our seizure medications can cause harm but so can seizures. Glass and colleagues1 provide important and robust evidence to address this contentious issue. Their data from 9 American Neonatal Seizure Registry centers suggest that prolonged antiseizure medication (ASM) treatment is unnecessary for most neonates and support routine discontinuation of ASMs after resolution of acute symptomatic neonatal seizures prior to hospital discharge.
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Payne ET, Wirrell EC. Discontinuing Antiseizure Medication in Neonates With Acute Symptomatic Seizures—Primum non nocere. JAMA Neurol. 2021;78(7):797–799. doi:10.1001/jamaneurol.2021.1218
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