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May 24, 2021

Discontinuing Antiseizure Medication in Neonates With Acute Symptomatic Seizures—Primum non nocere

Author Affiliations
  • 1Pediatric Neurocritical Care & Epilepsy, Section of Neurology, Department of Pediatrics, Alberta Children’s Hospital & the University of Calgary, Calgary, Alberta, Canada
  • 2Department of Neurology, Mayo Clinic, Rochester, Minnesota
JAMA Neurol. 2021;78(7):797-799. doi:10.1001/jamaneurol.2021.1218

In the field of epilepsy treatment, we are often caught between the proverbial rock and hard place: our seizure medications can cause harm but so can seizures. Glass and colleagues1 provide important and robust evidence to address this contentious issue. Their data from 9 American Neonatal Seizure Registry centers suggest that prolonged antiseizure medication (ASM) treatment is unnecessary for most neonates and support routine discontinuation of ASMs after resolution of acute symptomatic neonatal seizures prior to hospital discharge.

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