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July 19, 2021

Young-Onset Dementia—New Insights for an Underappreciated Problem

Author Affiliations
  • 1Department of Neurology, Mayo Clinic, Rochester, Minnesota
JAMA Neurol. 2021;78(9):1055-1056. doi:10.1001/jamaneurol.2021.1760

At one time in the not-too-distant past, young-onset dementia (YOD) was considered a disease, whereas later-onset dementia (LOD) was considered the inevitable consequence of aging. We now reject such a formulation, but within that misguided dichotomy is a recognition of the dramatic differences in prevalence and incidence of YOD compared with LOD. In this issue of JAMA Neurology, Hendriks et al1 quantitate dementia prevalence in persons aged 30 to 64 years through a meta-analysis of 74 individual studies.

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