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Comment & Response
August 2, 2021

Adequate Initial Dosage and Tapering Methods of Steroids to Reduce the Total Corticosteroid Dose in Myasthenia Gravis—Reply

Author Affiliations
  • 1Institute of Myology, Paris, France
  • 2Hôtel Dieu Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
  • 3General Intensive Care Unit, GHU–Psychiatrie and Neurosciences, Site Sainte-Anne, Paris, France
JAMA Neurol. 2021;78(9):1153-1154. doi:10.1001/jamaneurol.2021.2495

In Reply We thank Akamine et al for their letter. They have raised the concern that corticosteroids can lead to initial myasthenia gravis (MG) worsening. Our data (Table) demonstrate that, in fact, there was no greater deterioration in the rapid-tapering arm compared with the slow-tapering arm in the first month following corticotherapy treatment. Additionally, there was greater improvement in the Myasthenia Muscle Score in the rapid-tapering arm (Table). We agree that initial worsening with corticosteroids has been a long-standing concern of neurologists treating patients with MG. According to a recent systematic review,2 there is insufficient evidence to conclude that high-dose corticotherapy increases exacerbation in MG. Furthermore, our study1 demonstrated that high-dose corticosteroids can be prescribed in MG without significant deterioration.

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