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Comment & Response
August 2, 2021

Adequate Initial Dosage and Tapering Methods of Steroids to Reduce the Total Corticosteroid Dose in Myasthenia Gravis

Author Affiliations
  • 1Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan
JAMA Neurol. 2021;78(9):1153. doi:10.1001/jamaneurol.2021.2492

To the Editor We read the interesting article by Sharshar and colleagues1 and appreciate the authors’ efforts to answer the long-standing question of which incremental or decremental methods of prednisone dosage are better for the treatment of patients with myasthenia gravis (MG). There was a significant difference in the primary outcome between the slow-tapering and rapid-tapering groups. The percentage of patients with no MG symptoms who could wean off prednisone was higher in the rapid-tapering group. Moreover, patients in the rapid-tapering group had a lower cumulative dosage of prednisone. However, we would like to point out 2 concerns.

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