Major surgery is often complicated by postoperative neurocognitive disorder. Affected patients exhibit problems with memory and executive function, similar to deficits seen in Alzheimer disease (AD).1,2 A critical question is whether surgery can exacerbate or unmask latent pathophysiology underlying the development of AD.2
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Feinstein I, Wilson EN, Swarovski MS, Andreasson KI, Angst MS, Greicius MD. Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Noncardiac Surgery. JAMA Neurol. Published online September 20, 2021. doi:10.1001/jamaneurol.2021.2823
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