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Research Letter
September 20, 2021

Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Noncardiac Surgery

Author Affiliations
  • 1Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California
  • 2Department of Neurology and Neurological Sciences, Stanford University, Stanford, California
JAMA Neurol. Published online September 20, 2021. doi:10.1001/jamaneurol.2021.2823

Major surgery is often complicated by postoperative neurocognitive disorder. Affected patients exhibit problems with memory and executive function, similar to deficits seen in Alzheimer disease (AD).1,2 A critical question is whether surgery can exacerbate or unmask latent pathophysiology underlying the development of AD.2

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