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Comment & Response
October 4, 2021

Traumatic Brain Injury Recovery Trajectories in Patients With Disorders of Consciousness

Author Affiliations
  • 1Section of Surgical Sciences, Surgical Critical Care, and Emergency General Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee
JAMA Neurol. 2021;78(11):1411. doi:10.1001/jamaneurol.2021.3433

To the Editor We congratulate Kowalski et al1 for their longitudinal nested cohort of patients with moderate to severe traumatic brain injury (TBI) using the long-standing, federally supported Traumatic Brain Injury Model Systems (TBIMS) National Database,2 which has 3 decades of follow-up. Their findings are remarkable in that the majority (82%) of initially comatose patients recovered consciousness after a stay in an inpatient rehabilitation center. More impressive is that 2 of 5 patients with disorders of consciousness (DOC) regained either partial or full independence. However, there are several interesting limitations that we thought were worth highlighting to the JAMA Neurology readership.

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