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Research Letter
October 11, 2021

Changes in Blood Biomarkers of Brain Injury and Degeneration Following Long-Duration Spaceflight

Author Affiliations
  • 1Institute for Neuroradiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany
  • 2Department of Anesthesiology, University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany
  • 3Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
  • 4Institute of Biomedical Problems of the Russian Academy of Sciences (SSC RF-IBMP RAS), Moscow, Russia
JAMA Neurol. Published online October 11, 2021. doi:10.1001/jamaneurol.2021.3589
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    1 Comment for this article
    Clinical significance may suffice
    Sandro Tsang, PhD | People's Open Access Education Initiative
    The blood samples were collected from five male cosmonauts. The letter did not specify which correlation measure was applied. If Pearson correlation coefficient was applied, then the sample size was too small to obtain reliable results. The results showed a significant association of NfL, GFAP, and Aβ40 levels with each other across the participants and times by the widely adapted P<0.05 threshold. However, only the association between Aβ40 and Aβ42 was shown to be strong, as its correlation (r = 0.885, P < .001) surpassed the widely adapted minimum acceptable explained variance (r^2=0.783>0.5). I am looking forward to learning more about the clinical significance of the findings.