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March 14, 2022

Diagnostic Challenges and Uncertainties of Embolic Strokes of Undetermined Source in Young Adults

Author Affiliations
  • 1Faculty of Medicine, School of Health Sciences, Department of Internal Medicine, University of Thessaly, Larissa, Greece
  • 2Department of Neurology, University of Colorado School of Medicine, Aurora
JAMA Neurol. 2022;79(5):444-447. doi:10.1001/jamaneurol.2022.0058

Nearly 10% to 15% of acute ischemic strokes occur in young adults, with the incidence steadily increasing over the past few decades.1 Approximately 20% to 40% of these young patients with stroke are classified as having embolic strokes of undetermined source (ESUS), as the underlying stroke etiology cannot be reliably identified despite recommended diagnostic workup.2 The young ESUS population is an understudied group, as only a few studies, limited by their small size and the lack of prospective follow-up, have assessed their characteristics and outcomes.3-6

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