Original Investigation
Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease
Yann Le Guen, PhD; Michael E. Belloy, PhD; Benjamin Grenier-Boley, MSc; Itziar de Rojas, MSc; Atahualpa Castillo-Morales, PhD; Iris Jansen, PhD; Aude Nicolas, PhD; Céline Bellenguez, PhD; Carolina Dalmasso, PhD; Fahri Küçükali, PhD; Sarah J. Eger, BA; Katrine Laura Rasmussen, MD, PhD; Jesper Qvist Thomassen, PhD; Jean-François Deleuze, PhD; Zihuai He, PhD; Valerio Napolioni, PhD; Philippe Amouyel, MD, PhD; Frank Jessen, MD; Patrick G. Kehoe, PhD; Cornelia van Duijn, PhD; Magda Tsolaki, MD, PhD; Pascual Sánchez-Juan, MD, PhD; Kristel Sleegers, MD, PhD; Martin Ingelsson, MD, PhD; Giacomina Rossi, PhD; Mikko Hiltunen, PhD; Rebecca Sims, PhD; Wiesje M. van der Flier, PhD; Alfredo Ramirez, MD, PhD; Ole A. Andreassen, MD, PhD; Ruth Frikke-Schmidt, MD, PhD; Julie Williams, PhD; Agustín Ruiz, MD, PhD; Jean-Charles Lambert, PhD; Michael D. Greicius, MD; Members of the EADB, GR@ACE, DEGESCO, DemGene, GERAD, and EADI Groups; Beatrice Arosio, PhD; Luisa Benussi, PhD; Anne Boland, PharmD, PhD; Barbara Borroni, MD; Paolo Caffarra, PhD; Delphine Daian, MSc; Antonio Daniele, MD, PhD; Stéphanie Debette, MD, PhD; Carole Dufouil, PhD; Emrah Düzel, MD, PhD; Daniela Galimberti, PhD; Vilmantas Giedraitis, PhD; Timo Grimmer, PhD; Caroline Graff, MD; Edna Grünblatt, PhD; Olivier Hanon, MD; Lucrezia Hausner, PhD; Stefanie Heilmann-Heimbach, PhD; Henne Holstege, PhD; Jakub Hort, MD, PhD; Deckert Jürgen, MD; Teemu Kuulasmaa, MSc; Aad van der Lugt, PhD; Carlo Masullo, MD; Patrizia Mecocci, MD, PhD; Shima Mehrabian, PhD; Alexandre de Mendonça, PhD; Susanne Moebus, PhD; Benedetta Nacmias, PhD; Gael Nicolas, MD, PhD; Robert Olaso, PhD; Goran Papenberg, PhD; Lucilla Parnetti, MD, PhD; Florence Pasquier, MD, PhD; Oliver Peters, MD; Yolande A. L. Pijnenburg, MD; Julius Popp, MD; Innocenzo Rainero, MD, PhD; Inez Ramakers, PhD; Steffi Riedel-Heller, MD; Nikolaos Scarmeas, MD, PhD; Philip Scheltens, MD, PhD; Norbert Scherbaum, MD; Anja Schneider, MD; Davide Seripa, PhD; Hilkka Soininen, MD, PhD; Vincenzo Solfrizzi, MD, PhD; Gianfranco Spalletta, MD, PhD; Alessio Squassina, PhD; John van Swieten, MD; Thomas J. Tegos, MD, PhD; Lucio Tremolizzo, MD, PhD; Frans Verhey, MD, PhD; Martin Vyhnalek, MD, PhD; Jens Wiltfang, MD; Mercè Boada, MD, PhD; Pablo García-González, MSc; Raquel Puerta, MSc; Luis M. Real, PhD; Victoria Álvarez, PhD; María J. Bullido, PhD; Jordi Clarimon, PhD; José María García-Alberca, MD, PhD; Pablo Mir, MD, PhD; Fermin Moreno, MD, PhD; Pau Pastor, MD, PhD; Gerard Piñol-Ripoll, MD, PhD; Laura Molina-Porcel, MD, PhD; Jordi Pérez-Tur, PhD; Eloy Rodríguez-Rodríguez, MD, PhD; Jose Luís Royo, PhD; Raquel Sánchez-Valle, MD, PhD; Martin Dichgans, MD; Dan Rujescu, MD
JAMA Neurology