The concept of spasm of the cerebral arteries is of particular importance as regards its relationship to ruptured intracranial aneurysms. Vasospasm has long been suspected as a cause of cerebral ischemia in a variety of conditions, but proof of its occurrence in the human subject has been particularly difficult to obtain, for reasons that are obvious. The uncritical use of the term "vasospasm" as an explanation of cerebral ischemia in vascular disease of the brain has been rightly criticized by Denny-Brown1 and others. Pickering2 was of the opinion that true spasm is a rare condition. However, since the advent and widespread usage of cerebral angiography in the diagnosis of subarachnoid hemorrhage, it has become evident that spasm of the major cerebral arteries not infrequently occurs after the rupture of an intracranial aneurysm. Direct observation of the constricted vessels at surgery has been reported with increasing frequency since
FLETCHER TM, TAVERAS JM, POOL JL. Cerebral Vasospasm in Angiography for Intracranial Aneurysms: Incidence and Significance in One Hundred Consecutive Angiograms. JAMA Neurol. 1959;1(1):38–47. doi:10.1001/archneur.1959.03840010040005
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.