The common concept of encephalomalacia as an atrophic or a nonexpanding lesion stems from the appearance of the lesion which has been present for a considerable time and in which a sharply delimited destructive lesion has produced decreased bulk of the brain, and perhaps even enlargement of the ventricular system toward the lesion. The appearance of the corresponding lesion of short duration has received relatively little comment, although references to its edematous appearance can be found in the old, as well as in the recent, literature.
Recent reports concerning swelling of the brain following massive infarction, often with thrombosis of the internal carotid artery, prompted the following study to determine whether such swelling was a regular occurrence following acute infarction of the brain and, if so, to determine the degree and duration of the swelling.
In an attempt to limit the number of possible variable factors, only those cases
CHENG-MEI S, ALVORD EC, BERRY RG. Swelling of the Brain Following Ischemic Infarction with Arterial Occlusion. AMA Arch Neurol. 1959;1(2):161–177. doi:10.1001/archneur.1959.03840020035006
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