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Article
September 1959

Effects of Lysergic Acid Diethylamide (LSD) on Cortical Sensory Evoked Potentials in the Cat

Author Affiliations

Baltimore
From the Division of Neurological Surgery, The Johns Hopkins University School of Medicine.
Present address (Dr. Finney) U. S. Naval Hospital, Chelsea, Mass.

AMA Arch Neurol. 1959;1(3):258-268. doi:10.1001/archneur.1959.03840030016002
Abstract

Introduction  Several authors have reported the effects of lysergic acid diethylamide (LSD) on evoked potentials in primary sensory pathways. The areas studied were retina,2 lateral geniculate body,8 and visual,9,14,18 auditory,14,18 and somatic cortex.14 There is incomplete agreement on the effects of LSD on visual and auditory cortex. Purpura14 found facilitation of visual cortical potentials with small doses, whereas Evarts8 found no significant effect with very large doses. Rovetta18 used LSD topically and intravenously in small doses and reported an absence of effect onboth visual and auditory potentials. Large doses of the drug have been used infrequently.Numerous authors have described the effects of LSD on the electrocorticogram of several species of animals.* There is a great variation in the dose reported to produce a significant change in frequency and amplitude, as well as disagreement regarding the character of the changes.

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