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September 1959

A Study of Coagulation Factors in Blood and Spinal Fluid in Multiple Sclerosis

Author Affiliations

Richmond, Va.
National Foundation Fellow in Clinical Pathology and Physical Medicine and Rehabilitation, Medical College of Virginia (Dr. Albright). Professor and Chairman, Department of Clinical Pathology, Medical College of Virginia (Dr. Kupfer).

AMA Arch Neurol. 1959;1(3):315-326. doi:10.1001/archneur.1959.03840030073008

Introduction  For over 90 years, since Charcot, a French neurologist, correlated the clinical and pathological changes associated with the disease designated as multiple sclerosis, many theories as to its etiology have been advanced. Theories pertaining to changes in vascular and blood factors are still controversial and consequently subjected to investigation. Changes in cerebrospinal fluid are also believed by many investigators to be of etiologic significance.The following study was undertaken to determine whether the spinal fluid of normal subjects and/or of patients with multiple sclerosis has tissue and/or blood thromboplastic activity. Blood vessel fragility, coagulation factors, and platelets were investigated by current methods in cases of clinically well-established multiple sclerosis. The study also included evaluation of serum platelet-like activity and determination of sedimentation rates and cerebrospinal fluid protein levels.Results obtained revealed that there is neither blood nor tissue thromboplastic activity in the spinal fluid of normal subjects or of

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