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October 1959

Studies on Cerebral Oxygenation During Induced Hypotension

Author Affiliations

From the Division of Neurosurgery, Department of Surgery, University of Cincinnati College of Medicine.

AMA Arch Neurol. 1959;1(4):443-451. doi:10.1001/archneur.1959.03840040087005

Although induced hypotension is being employed less frequently now than previously, the method still has clinical value as an adjunct in the surgical management of certain vascular and neoplastic lesions. The present study was undertaken in an attempt to elucidate by a new technique the cerebral hemodynamics associated with induced hypotension. Previous literature concerning hypotension contains numerous references to a "safe" or "critical" level of blood pressure below which cerebral nutrition is impaired. The basis for these terms, however, has remained obscure because of difficulty encountered in measuring rapidly occurring or minor variations in cerebral oxygenation. The present work is an effort to determine whether there does exist a critical level of blood pressure for maintenance of adequate cerebral oxygenation. In addition, a comparison is made between the effect of chemical-induced hypotension and the effect resulting from blood loss, since each method has been advocated on certain theoretical or experimental

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