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December 1959

A Restricted Form of Cerebellar Cortical Degeneration Occurring in Alcoholic Patients

Author Affiliations

From the Neurology Service, Massachusetts General Hospital, and the Departments of Neurology and Neuropathology, Harvard Medical School.
Present address (Dr. Mancall): Department of Neurology, Jefferson Medical College, Philadelphia.

AMA Arch Neurol. 1959;1(6):579-688. doi:10.1001/archneur.1959.03840060001001


Clinical Observations

The Natural History of the Disease

Clinical and Pathological Case Reports

A Quantitative Estimation of the Changes in the Cerebellar Cortex


A. Clinical Features

B. Nature and Significance of the Pathological Findings

C. Clinical and Pathological Correlation

D. Etiological Considerations

E. Review of the Medical Literature

F. Spontaneously Occurring Cortical Cerebellar Degenerations in Animals

G. Restricted Cortical Cerebellar Degeneration in the Alcoholic Patient—a Clinical-Pathological Entity

Summary and Conclusions

Introduction  The relationship of cerebellar cortical degeneration to chronic alcoholism has been a controversial matter for many years. There are now several published accounts of a cerebellar syndrome in alcoholic patients, but these are purely clinical, and one has no way of ascertaining the nature of the pathological changes and of deciding whether they differed in any way from the other known types of cerebellar atrophy. Isolated, pathologically verified instances of primary cerebellar degeneration have been described in

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