In recent years the tremor and rigidity due to Parkinsonism, and indeed other motion disorders, have been profoundly influenced by artificially produced destructive lesions in or near the globus pallidus. These have been established chiefly by (1) purposeful infarction (ligation of the anterior choroidal artery1); (2) chemical (procaine2,3 or alcohol4,5) injection; (3) electrical cauterization6; (4) application of ultrasound radiation,7 and (5) surgical ablation and transection.8
It is well known that the symptom complex characterizing the Parkinsonian syndrome may result from a variety of conditions—encephalitis, cerebral arteriosclerosis, neoplasia, carbon monoxide poisoning, hepatolenticular degeneration, and others as well.9 Although pathologic lesions are encountered in the thalamus, cortex, and hypothalamus,9 characteristic atrophic changes are found most frequently in the cells of the globus pallidus and substantia nigra.10 The significance of these degenerative lesions with regard to the
WHITE RJ, MacCARTY CS, BAHN RC. Neuropathologic Review of Brain Lesions and Inherent Dangers in Chemopallidectomy: Report of a Case of Bilateral Pallidal Destruction. AMA Arch Neurol. 1960;2(1):12–18. doi:10.1001/archneur.1960.03840070014002
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