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March 1960

Concentric Lacunar Leukoencephalopathy

AMA Arch Neurol. 1960;2(3):266-273. doi:10.1001/archneur.1960.03840090030004

The group of diseases included under the general name of "leukoencephalopathy" comprises various pathoanatomic and pathogenic conditions. Their etiology is unknown. There is no satisfactory classification, and occasionally a new, equally obscure condition is added to this heterogeneous group.

The purpose of this paper is to describe an unusual and not hitherto described condition of the cerebral white matter and to discuss its relationship to the concentric sclerosis of Baló.

Report of a Case 

Clinical Data.  —A 30-year-old white woman had been well until five years prior to death, when she noted failing vision. This condition progressed during the next three years, with excerbations to the point of temporary loss of vision in one or both eyes and with partial remissions, usually following treatment with cortisone. The disease was generally progressive; and two years prior to death she was "almost blind"; her memory began to fail, and she became emotionally

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