The correlation of symptoms with changes in anatomic structure is a classic method of investigating the nervous system. From such studies much valuable information of normal and abnormal functions may be obtained. In clinical cases, however, one is rarely presented with discrete lesions of single structures. Most frequently the lesions are multiple or involve a number of structures. There is a temptation to ignore the lesions which do not seem to be pertinent. For this reason, clinical and pathological observations need to be supplemented with the results of animal experiments. This is particularly true in studies of the brain stem, in which a large number of structures with varied functions are compressed into a small volume. The present study is concerned with the functions of the median longitudinal fasciculus (MLF). This will be based on (a) review of previously reported cases, (b) results of animal experiments, and (c) report of
CHRISTOFF N, ANDERSON PJ, NATHANSON M, BENDER MB. Problems in Anatomic Analysis of Lesions of the Median Longitudinal Fasciculus. AMA Arch Neurol. 1960;2(3):293–304. doi:10.1001/archneur.1960.03840090057007
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