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April 1960

Cerebral Hemorrhage in Leukemia

Author Affiliations

Rochester, Minn.
Fellow in Medicine, Mayo Foundation (Dr. Groch). Section of Pathologic Anatomy (Dr. Sayre), and Section of Medicine (Dr. Heck), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn. is a part of the Graduate School of the University of Minnesota.

AMA Arch Neurol. 1960;2(4):439-451. doi:10.1001/archneur.1960.03840100077011

Although hemorrhage of the brain is a well-known potential complication in every case of leukemia, there are few detailed reports in the literature that deal with the incidence of this complication, and the controversy over the basic cause of such hemorrhage remains unsettled. Is it primarily a perivascular infiltration of the brain substance, or is it primary hemorrhage consisting of blood and leukemic cells?

Therefore, it was thought worth while to review a series of cases of leukemia with the hope of answering the following questions: 1. How often does cerebral hemorrhage occur in a given group of leukemic patients? 2. In what subgroup of leukemia does hemorrhage occur most frequently? 3. Is there any direct correlation between disturbances in coagulation and the appearance of cerebral hemorrhage? 4. What parts of the brain are involved most frequently? 5. What is the incidence of neurologic symptoms? 6. What is the microscopic

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