Although hemorrhage of the brain is a well-known potential complication in every case of leukemia, there are few detailed reports in the literature that deal with the incidence of this complication, and the controversy over the basic cause of such hemorrhage remains unsettled. Is it primarily a perivascular infiltration of the brain substance, or is it primary hemorrhage consisting of blood and leukemic cells?
Therefore, it was thought worth while to review a series of cases of leukemia with the hope of answering the following questions: 1. How often does cerebral hemorrhage occur in a given group of leukemic patients? 2. In what subgroup of leukemia does hemorrhage occur most frequently? 3. Is there any direct correlation between disturbances in coagulation and the appearance of cerebral hemorrhage? 4. What parts of the brain are involved most frequently? 5. What is the incidence of neurologic symptoms? 6. What is the microscopic
GROCH SN, SAYRE GP, HECK FJ. Cerebral Hemorrhage in Leukemia. AMA Arch Neurol. 1960;2(4):439–451. doi:10.1001/archneur.1960.03840100077011
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