The role of perinatal events in producing defect has long aroused both interest and controversy. Recently, attention has centered on those perinatal experiences which reduce the oxygen supply and lead to anoxia or asphyxia.* That anoxia can cause death is not doubted. The question is whether or not, if the organism survives, there are permanent residual effects.
The present study was undertaken to determine what residual effects, if any, follow perinatal anoxia in the human organism. Essentially, the procedure consisted of studying a number of newborn infants and then reexamining them at the age of 3 years.
The original sample consisted of 717 newborn infants, gathered over a period of two and one-half years. Of this group, 421 were chosen for the three-year follow-up study. Children were excluded if they had mild or questionable complications or congenital defects, or if they had not been born on the inpatient service of
ERNHART CB, GRAHAM FK, THURSTON D. Relationship of Neonatal Apnea to Development at Three Years. AMA Arch Neurol. 1960;2(5):504–510. doi:10.1001/archneur.1960.03840110018003
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