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May 1960

Respiratory and Cardiovascular Responses to Experimental Cerebral Emboli

Author Affiliations

Winston-Salem, N.C.
From the Sections of Neurology and Neurosurgery and the Department of Pathology of the Bowman Gray School of Medicine of Wake Forest College.

AMA Arch Neurol. 1960;2(5):556-564. doi:10.1001/archneur.1960.03840110070009

In previous experiments19 induced cerebral embolism in animals resulted in marked fluctuations in arterial and venous pressure and respiratory rate. Death often occurred within a few minutes after the injection of emboli.

The experiments discussed in this paper were designed to determine the extent of these circulatory and respiratory changes and to explain the cause of sudden death. Embolic material was injected into the internal carotid artery of dogs while the electrocardiogram (ECG), respirations, and arterial, venous, and cerebrospinal fluid (CSF) pressures were continuously recorded. A primary effect on respiration was noted in each experiment, with secondary effects on the vascular and CSF pressures and the ECG.

Materials and Methods  Seventeen stock dogs were used, ranging from 11 to 26 kg. They were anesthetized with intravenous pentobarbital sodium without premedication. The barbiturate was given in a dose of 30 mg. per kilogram of body weight.Three Sanborn transducers and