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June 1960

Arterial Oxygen Saturation and Alveolar Carbon Dioxide During Electroencephalography: I. Comparison of Hyperventilation and Induced Hypoxia in Subjects Without Brain Disease

Author Affiliations

From the Departments of Neurology, Wayne State University College of Medicine and the City of Detroit Receiving Hospital.

AMA Arch Neurol. 1960;2(6):631-643. doi:10.1001/archneur.1960.03840120037005

An investigation of the usefulness of induced hypoxia as an activation technique in electroencephalography will be reported in this and in following communications. Arterial oxygen saturation and, in most instances, alveolar carbon dioxide content (CO2) have been recorded concurrently with the EEG in 108 human subjects during induction of hypoxia by means of the inhalation of gas mixtures low in oxygen. Observations in normal subjects will be reported in this paper. Subsequent papers will present observations in subjects suffering from various types of epilepsy21 and cerebrovascular disease.22

A comparison of the EEG effects of hypoxia and other commonly used activation techniques was undertaken in this group of subjects for a number of reasons. Cerebral hypoxia induced by breath holding has been reported to be a useful activation technique by several investigators,2,11,17,27 but many patients are unable to hold their breath sufficiently long to induce EEG changes.

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