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June 1960

Arterial Oxygen Saturation and Alveolar Carbon Dioxide During Electroencephalography: II. Comparison of Hyperventilation and Induced Hypoxia in Subjects with Epilepsy

Author Affiliations

From the Departments of Neurology, Wayne State University College of Medicine and the City of Detroit Receiving Hospital.

AMA Arch Neurol. 1960;2(6):644-656. doi:10.1001/archneur.1960.03840120050006

In a previous communication11 the results of a study of electroencephalographic (EEG) activation in 37 normal subjects by the use of inhalation of a mixture of 7% oxygen and 93% nitrogen were presented. In this paper the results of the test in 26 subjects suffering from various types of epilepsy will be reported. In all subjects the arterial oxygen saturation and alveolar carbon dioxide concentration (CO2) were continuously recorded with the EEG, and the effects of hypoxia were compared with other activation procedures, such as hyperventilation, breath holding, and, in some subjects, ocular compression.3 The effects of breathing 7% CO2 and oxygen mixtures, of breathing 100% oxygen, and of intravenous injection of sodium bicarbonate on induced seizure discharges were also evaluated.

Before we proceed with a detailed account of the methods and results of the present study, the history of the use of hyperventilation and

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