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November 1960

Neurologic Aspects of Waldenström's Macroglobulinemia: Report of a Case

Author Affiliations

From the Division of Neurology, University of Minnesota Medical School, and the Department of Pathology, Minneapolis General Hospital.

Arch Neurol. 1960;3(5):564-573. doi:10.1001/archneur.1960.00450050084010

Introduction  In 1944 Waldenström described a clinical syndrome under the title "incipient myelomatosis"1 which he subsequently renamed "macroglobulinemia."2 S i n c e that time about 200 similar cases were reported principally in the foreign literature. A number of recent reviews3-6 have established the following as the outstanding characteristics of the disease.1. It is a chronic debilitating illness primarily affecting males between the ages of 50 and 80. The usual life expectancy after the first manifestation of symptoms is 2 to 10 years.2. The onset is insidious, usually characterized by progressive weakness, lassitude, weight loss, and pallor. Edema may be present.3. Hemorrhagic diathesis is present in at least two-thirds of the cases and is manifested primarily by epistaxis, gingival and retinal hemorrhages, cutaneous p u r p u r a (usually late), and to a lesser extent bleeding from other organs.4. Painless enlargement

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