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December 1960

Antibacterial Drugs Topically Applied to the Central Nervous System: Experimental Evaluation

Author Affiliations

Montreal, Canada
From The Department of Neurology and Neurosurgery, McGill University and The Montreal Neurological Institute.

Arch Neurol. 1960;3(6):665-676. doi:10.1001/archneur.1960.00450060053006

The great variability of the effects of topically applied antibiotic and chemotherapeutic drugs to the central nervous system is not generally appreciated, in spite of numerous clinical and experimental studies.

Many of these drugs are epileptogenic. Others are severe cortical "depressants," and still others have no significant effect on the electrical activity or histological appearance of the central nervous system. To keep up with the rapid development of new antibacterial agents, Hanbery and Ajmone-Marsan1 in 1954 investigated the effects on the central nervous system of chloramphenicol, penicillin, streptomycin, bacitracin, neomycin, erythromycin, chlortetracycline (Aureomycin), oxytetracycline (Terramycin), and polymyxin B. Before this, Russell and Falconer,2 Jasper et al,3 and Botterell et al4 investigated the effects of various sulfonamides on the brain; Walker et al5,6 investigated the effects of penicillin on the cortex; and Teng et al7,8 studied bacitracin.

Newer drugs are coming on the market all