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January 1961

Reversible Block of Nerve Conduction by Ultrasound: Ultrasonic Blocking of Nerve Fibers

Author Affiliations

Departments of Surgery (Neurosurgery) and Physiology Harvard Medical School.

Arch Neurol. 1961;4(1):83-89. doi:10.1001/archneur.1961.00450070085009

Introduction  In recent years ultrasound has found a number of important applications to biological problems. In particular, its destructive effects on the nervous system promise to be of experimental as well as practical value.1-4 In appropriate dosage it may enhance or depress the functional activity of the central nervous system.5,6 Little is known about these functional effects, which do not necessarily involve the production of detectable lesions. This study on peripheral nerve was undertaken to investigate the effects of focused ultrasound on axonal conduction in a mixed nerve, and to shed light on the nature of the central effects.

Methods  The sciatic nerves of large green frogs were used. The branches in the thigh were cut and the main trunk with its tibial and peroneal extensions, measuring about 7 cm. in length, was removed. Distally the tibial and peroneal branches were tied together. The nerve was mounted in

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