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June 1961


Author Affiliations

President; Secretary May 3, 1960

Arch Neurol. 1961;4(6):685-694. doi:10.1001/archneur.1961.00450120099011

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Presidential Address: Some Reflections on the Clinical Aspects of Cerebral Atherosclerosis.  DR. MEYER BROWN.Cerebral atherosclerosis is a very important subject because large numbers of persons are affected with this condition, because it frequently causes crippling disability or sudden death, because it requires the cooperative efforts of neurologist, internist, pathologist, biochemist, and more recently neurosurgeon, because therapeutic weapons that are being used for this condition still need proper assessment, and finally because we are woefully ignorant as to the precise pathophysiologic process which is taking place in each patient with this condition.Early concepts of cerebrovascular disease were relatively simple. A segment of the brain was alleged to suffer a sudden loss of function because of occlusion or rupture of its nutrient vessel. It soon became apparent that many anatomical and physiological factors affect the clinical manifestations of cerebral atherosclerosis. These include such intracranial factors as collateral blood supply, stenosis

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