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August 1961

Post-Lesion Tremor Inhibition: Effect of Tremorine After Lesions of the Hypothalamus and Thalamus

Author Affiliations

From the Departments of Neurology and Anatomy, State University of Iowa.
Dr. E. G. Hamel is presently with the Department of Anatomy, University of Alabama Medical Center, Birmingham, Ala.

Arch Neurol. 1961;5(2):221-226. doi:10.1001/archneur.1961.00450140103010

Introduction  Previous studies involving acute and chronic preparations indicated that transections of the neuraxis rostral to a plane passing through the head of the caudate nucleus, diagonal band of Broca, and the subcallosal gyrus, were ineffectual in preventing tremor at rest produced by the drug Tremorine (1,4 dipyrrolidino-2-butyne, Kaelber and Hamel1). Further attempts to localize ana tomical substrates through which this compound might be exerting some of its effects ultimately resulted in placing relatively circumscribed electrolytic lesions in various parts of the hypothalamus and certain ventrally situated thalamic nuclei. A number of these lesions proved to be effective against the tremor-producing properties of this drug.This report deals with a description of the lesions and areas destroyed relative to their effectiveness against Tremorine and some problems in correlation of specific structures with drug action.

Methods  Under pentobarbital (Nembutal) anesthesia bilateral electrolytic lesions were made in various parts of the

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