In 1888, Sanger-Brown and Schafer1 described an apparent disturbance of memory in monkeys after the partial or total removal of both temporal lobes. Two years later, Bechterew2 in a very brief report, described a patient who had shown an extraordinary degree of memory disturbance, as well as considerable apathy for many years; in the region of the gyrus uncinatus and Ammon's horn in each temporal lobe, the cortex and underlying structures were said to be softened. The matter then lay dormant until 1954, when Scoville3 described a grave loss of recent memory in 2 patients after resection of the medial parts of both temporal lobes. The ablations extended posteriorly along the medial surfaces for a distance of about 8 cm. from the tips of the temporal lobes, and probably destroyed the anterior two-thirds of the hippocampus and hippocampal gyrus bilaterally, as well as the amygdala. Later, these
VICTOR M, ANGEVINE JB, MANCALL EL, FISHER CM. Memory Loss with Lesions of Hippocampal Formation: Report of a Case with Some Remarks on the Anatomical Basis of Memory. Arch Neurol. 1961;5(3):244–263. doi:10.1001/archneur.1961.00450150010002
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