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December 1961

Studies on Headache: The Responses of the Bulbar Conjunctival Blood Vessels During Induced Oliguria and Diuresis, and Their Modification by UML-491

Author Affiliations

From the Study Program in Human Health and the Ecology of Man, and the Department of Medicine (Neurology), Cornell Medical Center, New York Hospital, New York.

Arch Neurol. 1961;5(6):590-593. doi:10.1001/archneur.1961.00450180012003

The phenomena of widespread fluid retention and subsequent diuresis which occur in patients with vascular headache of the migraine type have been well documented.1,2 In general, it was found that significant weight gain occurred in the period prior to the onset of head pain, and that diuresis usually followed during the time of dwindling headache intensity. The purpose of this paper was to observe the response of the bulbar conjunctival blood vessels to vasoconstrictor agents during oliguria and diuresis and the effect upon these vascular responses of the prior administration of UML-491 (1-methyl-d-lysergic acid butanolamide tartrate.

Method  Thirty-two experiments were performed on 17 subjects. A standard water load of 1,000 cc. was imbibed within 10 minutes and urine output in ml/min was then measured. The urine flow in ml/min was replaced in volume-for-volume fashion with additional water during the course of the experiment in order to maintain

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