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February 1962

Acute Necrotizing Encephalitis: A Diagnostic Problem in Temporal Lobe Disease: Report of Three Cases

Author Affiliations

From the Departments of Neurology, Pathology, and Neurosurgery, University of Wisconsin Hospitals.

Arch Neurol. 1962;6(2):96-113. doi:10.1001/archneur.1962.00450200010002

Introduction  The name "acute necrotizing encephalitis" (ANE), as coined by van Bogaert, Radermecker, and Devos1 in 1955, is used to designate a form of meningoencephalitis characterized by softening of the temporal lobes and related rhinencephalic structures, and microscopically by an extensive necrosis of these areas. During the past 2 decades, 59 cases of similar clinical and anatomical findings in patients over 1 year of age with a duration of illness less than 4 weeks have appeared in the literature.1-25 Patients under 1 year of age were omitted because the necrosis tends to be more generalized. The duration of illness was limited to 4 weeks to emphasize the acute diagnostic problem. In 46 of these, Type A intranuclear inclusions were found in nerve or neuroglial cells1-16; of 20 cases in which viral isolation studies were made on brain tissue,* 13 were positive for herpes simplex.2,3,11,12,15-20 The remaining

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