Disruption in learned performance by subcortical lesions has been shown to occur from widely separated diencephalic and mesencephalic areas. With small lesions in a variety of subcortical structures, disruption of learned avoidance behavior is temporary (1955, Brady and Nauta11), but, by contrast, in approach learning, longer-lasting effects have been described with lesions in the region of the entopeduncular nucleus in visual discriminative tasks (1960, Thompson21 ). With larger diencephalic lesions, persistence of cardiovascular and respiratory reflexes has been described (1959, Doty et al.12), but such larger lesions are associated with major behavioral defects in many areas, and discriminative motor performances are virtually lost.
We have been concerned in this study with restricted lesions in the region of the subthalamus and their effect on previously learned delayed response and T-maze performance. Our previous studies with somewhat larger lesions in this region have indicated interference with avoidance behavior in both
ADEY WR, WALTER DO, LINDSLEY DF. Subthalamic Lesions: Effects on Learned Behavior and Correlated Hippocampal and Subcortical Slow-Wave Activity. Arch Neurol. 1962;6(3):194–207. doi:10.1001/archneur.1962.00450210022003
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