In the last few years attention has been directed to the possible role of the ventrolateral area of the thalamus in the pathophysiology of tremor and rigor. Neurosurgical experience (Hassler and Riechert1; Cooper2) indicates that lesions of this region are able to influence favorably or to eliminate these pathological phenomena in patients with Parkinson's disease. An apparently plausible explanation for the success of these operations has been offered by Hassler.3 He subdivides into several zones, the nuclear area called by Walker4 and other American writers the nucleus ventralis lateralis. Of particular interest is the nucleus ventralis oralis anterior and posterior; the anterior nucleus receives impulses from the pallidum and it transmits them to the premotor cortex (area 6aα). Cerebellofugal impulses enter the nucleus ventralis oralis posterior; from here they are projected to the motor region (area 4γ). Hassler assumes that interruption of the cerebellothalamocortical pathway and
SPULER H, SZEKELY EG, SPIEGEL EA. Stimulation of the Ventrolateral Region of the Thalamus: Its Effect upon Tremor Induced by Midbrain Stimulation in Cats. Arch Neurol. 1962;6(3):208–219. doi:10.1001/archneur.1962.00450210036004
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