Primary intracranial tumors in general, and primary brain tumors in particular, rarely metastasize outside the cranial cavity. The scarcity of fully documented cases has prompted us to report 2 cases of primary brain tumors which at autopsy were found to have metastasized to extracranial organs.
Report of Cases
Case 1.—A 40-year-old white man developed signs and symptoms of increased intracranial pressure about 14 months prior to his death. Nine months before death a large portion of a tumor involving the right temporo-occipital area was removed. After the operation his symptoms subsided for a short time. He was referred to Roswell Park Memorial Institute, where 4 months prior to his death during a second craniotomy a partly cystic tumor was removed, along with 90% of the right occipital and part of the parietal and temporal lobes. A small piece of the tumor was immediately autografted into the right thigh. This
NIGOGOSYAN G, DE LA PAVA S, PICKREN JW. Brain Tumor with Extracranial Metastases: Report of Two Cases. Arch Neurol. 1962;6(4):300–306. doi:10.1001/archneur.1962.00450220042007
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