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April 1962

Dysrhythmia Associated with Proved Hypothalamic Disease: Fourteen- and Six-per-Second Dysrhythmia

Author Affiliations

Division of Neurology, Department of Medicine, Medical College of Alabama.

Arch Neurol. 1962;6(4):324-330. doi:10.1001/archneur.1962.00450220066010

Introduction  In 1951, Gibbs and Gibbs1 reported the now well-known patterns of 14- and 6-per-second positive spikes in the human electroencephalogram. In 19522 the same authors discussed the clinical significance of this pattern in more detail. They stated that this pattern was a reliable sign of disordered energy release in subcortical centers and suggested that the associated clinical manifestations might be called "thalamic and hypothalamic epilepsy." Although they found that 5% of the patients with this dysrhythmia had endocrine disturbances and another 5% had hypersomnia, they do not refer to any instances of proved hypothalamic disease.In 1956,3 however, Gibbs reviewed the clinical correlates of this pattern before a South American electroencephalographers' congress and stated that when this pattern was caused by brain tumors they were in, or impinged upon, the thalamus or hypothalamus. This report by Gibbs referred to a description by Stephenson4 of 2

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