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April 1962

Cerebrospinal Fluid Dynamics in Health and Disease.

Arch Neurol. 1962;6(4):334-335. doi:10.1001/archneur.1962.00450220076014

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This is a brief monograph, 67 pages, containing approximately 175 references to observations and experimental investigations over a span of two centuries, including the important advances of the past decade. Five chapters are devoted to citing the accumulated evidence bearing on the absorption of cerebrospinal fluid, the production of cerebrospinal fluid, dynamic factors, the mechanics and treatment of hydrocephalus, and to other disorders of cerebrospinal fluid mechanics. Investigations in animals and human subjects form the basis for much of the more recent data. The information presented does not as yet constitute solid proof for the proposed physiologic mechanisms, but it may be said that among the older hypotheses some stand as even more likely, whereas other notions must now be abandoned in favor of entirely fresh concepts which have emerged.

This work shows how the availability of new materials and new techniques, in this instance, physical chemical, involving radioactive isotopes,

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