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May 1962

The ABO Blood Groups and Muscular Dystrophy

Author Affiliations


Arch Neurol. 1962;6(5):387-389. doi:10.1001/archneur.1962.00450230049006

Of the 65 known blood-group antigens studied, each is inherited as a simple Mendelian dominant.1,2 This information can be used in studying the nature of inherited diseases in 2 ways. First, one may seek evidence for chromosomal linkage between any of the blood-group antigens and the disease under consideration. Furthermore, the occurrence of the blood groups may be documented to discover whether their frequency in a particular disease differs from their distribution in a comparable unaffected population. The purpose of this report is to review the accumulated evidence relating to the ABO blood-group antigens and the muscular dystrophies.

Materials and Methods  Forty-nine patients seen at the University of Oklahoma Medical Center were diagnosed as having muscular dystrophy. In each, the disorder was classified as to type on the basis of an analysis of the clinical, laboratory, and genetic features. The classification of Walton and Nattrass was used.3 The

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