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Article
June 1962

Myasthenic Syndrome with Associated Neuropathy: Report of a Case, Including Response to Curare Therapy

Author Affiliations

MINNEAPOLIS
From the Departments of Laboratory Medicine, Physical Medicine and Rehabilitation, and Anesthesiology, University of Minnesota Medical School.
Instructor in Laboratory Medicine and in Physical Medicine and Rehabilitation (Dr. Steidl); Instructor in Anesthesiology (Dr. Oswald), and Professor and Head, Department of Physical Medicine and Rehabilitation (Dr. Kottke), University of Minnesota Medical School.

Arch Neurol. 1962;6(6):451-461. doi:10.1001/archneur.1962.00450240029004
Abstract

Defects in neuromuscular transmission suggestive of myasthenia gravis have been found in association with a wide variety of disorders, including hyperthyroidism,1-8 myopathies,9-10 lupus erythematosis,11-12 malignancy,13-15 and polymyositis.16 A similar relationship has been reported in various neuropathies, viz., poliomyelitis,17-19 syringomyelia,1,20 amyotrophic lateral sclerosis,2,16,18,21 and a variety of other conditions affecting the anterior horn cells22; however, in none of these cases did myasthenia gravis appear as the primary disease.

This report is a study of a patient with apparent myasthenia gravis who developed striking resistance to conventional therapy, who ultimately proved to respond in part to repeated courses of "rest" therapy with curare, and who late in her illness showed unexpected evidence of motor neuron disease.

Report of Case  During November, 1955, it was noted that the patient, a previously healthy 12-year-old girl, was unable to smile, and that the corners of

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