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July 1962

Studies on Hepatocerebral Disease: IV. Portal-Systemic Encephalopathy in Chronic Schistosomiasis Japonica

Author Affiliations

The Third Department of Internal Medicine (Director: Prof. Dr. S. Okinaka), Faculty of Medicine, University of Tokyo.

Arch Neurol. 1962;7(1):1a-9. doi:10.1001/archneur.1962.04210010007001

The development of neurological disorders in chronic schistosomiasis japonica with its well-known liver involvement presents an excellent opportunity to study the pathogenesis of neurological manifestations of liver disease, which has not been fully understood. Ariizumi1 in 1952 and Okinaka et al.2 in 1953 reported involvement of the nervous system in schistosomiasis not due to embolism of ova. A systematic study of schistosomiasis japonica from the neurological standpoint Was therefore attempted. Clinical records of 3 cases, autopsy findings of 2 cases, and the results of an epidemiological survey in the endemic area constitute the present communication.

Case Records  Three cases with well-developed neurological disorders associated with chronic schistosomiasis japonica were hospitalized and extensively studied with methods of clinical investigation, including determination of hepatic blood flow and splenic portography.

Case 1.  —The patient was a 58-year-old female with positive reaction to the Schistosoma skin test. Family history was noncontributory except

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