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August 1962

Relation of Behavior to Cerebral Ventricular Fluid Protein Levels

Author Affiliations

Illinois State Psychiatric Institute.

Arch Neurol. 1962;7(2):146-159. doi:10.1001/archneur.1962.04210020068008

The following reasons prompted this inquiry: First, it was noticed that some patients' behavior "improved" considerably for periods of up to 3 weeks after ventriculography. Second, it was noticed that abnormally high protein levels in the ventricular fluid (V.F.) were encountered where the patient showed a marked disturbance of behavior without a gross neurological lesion, or other pathological findings. Third, the cerebrospinal fluid (CSF) of epileptic and other patients sensitizes the frog myoneural junction to stimulation with acetylcholine,1 and this property is thought to be associated with a lipoprotein.2 Finally, lumbar puncture is often tried as a remedy in status epilepticus.

In order to discover whether, in fact, a relationship exists between behavior disorders and V.F. protein levels, all cases with the appropriate observations available at the hospital have been included.

Material and Methods  There were in all 60 cases; they included diagnostic groups usually found in psychiatric

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