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September 1962

Hypothalamus and Gastric Ulceration: II. Production of Gastrointestinal Ulceration by Chronic Hypothalamic Stimulation

Author Affiliations

Medical Fellow, Division of Neurosurgery (Dr. Long); Medical Fellow, Department of Surgery (Dr. Leonard); Instructor, Division of Neurosurgery (Dr. Story); Professor and Director, Division of Neurosurgery (Dr. French).; From the Department of Surgery, Division of Neurosurgery, University of Minnesota.

Arch Neurol. 1962;7(3):176-183. doi:10.1001/archneur.1962.04210030014002

Introduction  It has been demonstrated in Part I of this communication that discrete hypothalamic destruction consistently results in acute gastrointestinal erosion. It seemed reasonable, therefore, to postulate that chronic stimulation in this area might also result in acute and possibly chronic ulceration. This study was undertaken to investigate this hypothesis.

Technique  Thirty healthy male and female cats weighing from 2.4 to 4.9 kg. were utilized in this study. Details of care of animals and operative procedures have been reported in Part I of this communication. The technique of electrode manufacture and placement will be presented.Electrodes were concentric in type, made of No. 32 Beldenamel wire (Belden Mfg. Co.), inserted through a 26-gauge stainless steel tubing. The tip of this wire was allowed to protrude 0.5 mm. beyond the tubing. The opposite end of the wire served as one terminal, while a second piece of No. 32 Beldenamel wire was

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