Previous investigation has shown that lesions in various areas of the thalamus and hypothalamus produce adverse effects upon learning ability and alter emotional responsivity in experimental animals. Schreiner et al.6 reported that lesions in the anterior thalamic nuclei of the cat caused reduction in reactivity to noxious stimuli and impairment in ability to respond to discrimination and bar press situations. Knott, Ingram, and Correll3 found that lesions in the premammillary region and in the area of the ventromedial nucleus of the hypothalamus caused marked impairment in the ability of cats to respond in a bar press apparatus, the ventromedial hypothalamic lesions in addition causing a marked propensity to emotional over-reactivity of the "rage" type, as originally shown by Wheatley.9 Ingram, in a preliminary report of work by this group,2 also indicated probable impairment in acquisition of a conditioned avoidance (escape) response following premammillary and ventromedial hypothalamic
DAHL D, INGRAM WR, KNOTT JR. Diencephalic Lesions and Avoidance Learning in Cats. Arch Neurol. 1962;7(4):314–319. doi:10.1001/archneur.1962.04210040066006
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