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October 1962

Somatotopic Localization in Rhesus Subthalamic Nucleus

Author Affiliations

Professor of Anatomy, Assigned to Neurology, Columbia University (Dr. Mettler); Senior Registrar, Department of Neurology, The London Hospital, London, E. 1, (Dr. Stern).; From the Departments of Anatomy and Neurology, Columbia University, N.Y.

Arch Neurol. 1962;7(4):328-329. doi:10.1001/archneur.1962.04210040080008

In 1947, Mettler and Whittier1 were able to produce abnormal bodily movements in monkeys by placing lesions in the subthalamic nucleus. These movements, occurring for the most part in the limbs, closely resembled those seen in ballism (flinging movements) or, more broadly, chorea ("dancing" movements). The method of producing them was to run a concentric electrode, carried in a stereotaxic apparatus, into the dorsofrontal part of the brain in such a way that it entered the subthalamic nucleus. After having traversed this for a variable distance, the uninsulated tip of the electrode came to rest at the spot where the desired lesion was produced by fulguration. Not all lesions were provocative of abnormal movements. If they were, the movements were more specifically like ballism when the lesions were squarely in the nucleus. The movements were of a more general variety (of choreoid type) when the lesions were located to

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