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October 1962

Hodgkin's Disease: Disease Presenting with Symptoms of Cranial Nerve Involvement

Author Affiliations

Present address of Dr. Burston: Consultant Pathologist, Group Laboratory, Mile End Hospital, Bancroft Road, London, E.1.; Department of Neurology and Psychological Medicine, St. Thomas's Hospital, London, S.E.1 (Dr. Lascelles); Department of Pathology, St. Thomas's Hospital Medical School (Dr. Burston).

Arch Neurol. 1962;7(4):359-364. doi:10.1001/archneur.1962.04210040111013

Neurological symptoms are by no means rare in Hodgkin's disease. Usually they are the result of either an invasion of the vertebral canal with compression of the spinal cord or of involvement of peripheral nerves; rarely they are attributable to intracranial deposits.1 Invasion of the tissues of the central nervous system in Hodgkin's disease is very rare and usually occurs only in the last stages of the disease.2 Reference has been found to only one case3 in which the presenting symptoms were neurological and caused by intracranial deposits of Hodgkin's tissue; in this case the brain substance was invaded. The case to be described is one of Hodgkin's disease in which the presenting symptoms were caused by involvement of several cranial nerves. The brain tissue was invaded, and the disease ran its course without the appearance of symptoms or signs of deposits in any other situation.