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November 1962

Sarcoidosis of the Central Nervous System: Report of a Case and Review of the Literature

Author Affiliations


Arch Neurol. 1962;7(5):442-449. doi:10.1001/archneur.1962.04210050078009

Introduction  The systemic nature of sarcoidosis has been recognized for many years,1 and its cutaneous, visceral, and lymphohematopoietic manifestations are well documented.2 Peripheral3 and cranial nerve involvement are not infrequent, the latter being present in half of the patients with uveoparotid fever.4 Invasion of the central nervous system, however, is unusual. It was first demonstrated pathologically in 1907, by Tillgren, in a case of sarcoid chorioependymitis.5 Twenty-one clinically well-documented cases of sarcoidosis of the central nervous system have been published since in which the diagnosis was substantiated at necropsy and 7 cases in which it was confirmed by surgical biopsy. Of these 29 cases of central nervous system sarcoidosis, 10 clinically simulated brain tumor.5-14The following case is of interest because it presented a clinical picture of multiple brain tumors associated with disturbances of the hypothalamic function. Needle biopsy suggested intracranial sarcoidosis. At autopsy,

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