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December 1962

Studies on Glioma Immunity in the Mouse

Author Affiliations

From the Division of Neurological Surgery, The Johns Hopkins University.

Arch Neurol. 1962;7(6):538-544. doi:10.1001/archneur.1962.04210060056004

Introduction  The urgent need for new approaches to the therapy of malignant tumors has prompted renewed interest in the role of immune processes and other host defense mechanisms in neoplastic disease. Although the role of immunological processes in such diseases remains poorly understood, considerable clinical and experimental evidence has been accumulated which indicates that immune mechanisms are of importance in certain types of malignant disease in the human.3,4,8-10The recognition of the importance of autoimmune processes in certain nonmalignant human diseases has also served to stimulate new interest in immune mechanisms.2,19 In the laboratory animal destructive lesions of certain tissues including brain, peripheral nerve, uveal tract, testicular germinal epithelium, and thyroid have been produced by sensitizing the animal against his own tissues.20 This sensitization has been produced by the combination of adjuvant with appropriate tissue antigen. Adjuvant, containing paraffin oil and killed acid-fast bacilli, has the property

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