By Leo Alexander, M.D.; Austin W. Berkeley, Ph.D., and Alene M. Alexander. Price, $7.50. Pp. 188. Charles C Thomas, Publisher, 321 E. Lawrence Ave., Springfield, Ill., 1961.
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The authors of this book have brought into print their enormous experience in multiple sclerosis. They emphasize the evaluation of treatment using their method for scoring changes in the status of the patient. Their scoring technique is probably too elaborate and complicated for the average practitioner, but for those interested in treatment trials in this disorder it may offer valuable assistance in appraising the effects of treatment. Perhaps the most important aspect of this book is the data given on the natural history of the disease.
A variety of therapies are discussed: blood transfusion, corticotropin, adrenal steroids, etc. While it appears that these therapies are of some value in the treatment of patients, as shown by the authors' scoring system indicating changes in disability resulting from the disease, it is inadvisable to accept their conclusions as to the efficacy of these treatments until a study with randomized controls has become
McDowell F. Multiple Sclerosis: Prognosis and Treatment. Arch Neurol. 1962;7(6):591–592. doi:10.1001/archneur.1962.04210060109016
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