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February 1963

Course and Prognosis in Amyotrophic Lateral Sclerosis

Arch Neurol. 1963;8(2):117-127. doi:10.1001/archneur.1963.00460020017001

In 1849, Duchenne (de Boulogne) described "muscular atrophy with fatty transformation,"1 * and a year later Aran, using Duchenne's material, elaborated the description and named the condition progressive muscular atrophy (P.M.A.).2 In 1860, Duchenne added his unsurpassed clinical depiction of "progressive muscular paralysis of the tongue, palate and lips," now known as progressive bulbar palsy.3 In 1868 Charcot delivered a lecture at the Salpetriere on the association of progressive muscular atrophy

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